Bioactive Secondary Metabolites from the Marine Sponge Genus Agelas

نویسندگان

  • Huawei Zhang
  • Menglian Dong
  • Jianwei Chen
  • Hong Wang
  • Karen Tenney
  • Phillip Crews
چکیده

The marine sponge genus Agelas comprises a rich reservoir of species and natural products with diverse chemical structures and biological properties with potential application in new drug development. This review for the first time summarized secondary metabolites from Agelas sponges discovered in the past 47 years together with their bioactive effects.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Effects of Agelas oroides and Petrosia ficiformis crude extracts on human neuroblastoma cell survival.

Among marine sessile organisms, sponges (Porifera) are the major producers of bioactive secondary metabolites that defend them against predators and competitors and are used to interfere with the pathogenesis of many human diseases. Some of these biological active metabolites are able to influence cell survival and death, modifying the activity of several enzymes involved in these cellular proc...

متن کامل

Multiple Defensive Roles for Bromopyrrole Alkaloids from Caribbean Agelas Sponges

Previous studies have indicated that Caribbean reef sponges of the common genus Agelas are chemically defended from fish predators by brominated pyrrole alkaloids: Agelas clathrodes and A. wiedenmayeri by 4,5-dibromopyrrole-2-carboxylic acid (1) and oroidin (2), A. conifera by sceptrin (3). In this study, we expand our understanding of chemical defense in this sponge genus to include an extensi...

متن کامل

Antimicrobial activities of semi polar-nonpolar and polar secondary metabolites of sponge Dysidea pallescens from Hengam Island, Persian Gulf

Sponges are the simplest multicellular animals that lack defense mechanisms and rely on chemical defense  that have been used by mankind to develop antimicrobial drugs against diseases.  The present study was designed to demonstrate the antibacterial and antifungal activities of marine sponge Dysidea pallescens semipolar and nonpolar extracts. In this study, D. pallescens were collected from He...

متن کامل

Sventrin, a new bromopyrrole alkaloid from the Caribbean sponge Agelas sventres.

A detailed analysis of the secondary metabolites of a specimen of Agelas sventres was carried out here for the first time. The chemistry of Agelas sponges is dominated by bromopyrrole derivatives. Besides three known bromopyrrole metabolites, a new compound, sventrin (1), was isolated and its structure identified using spectroscopic methods. Sventrin (1) was shown to be a feeding deterrent comp...

متن کامل

Bromoageliferin and dibromoageliferin, secondary metabolites from the marine sponge Agelas conifera, inhibit voltage-operated, but not store-operated calcium entry in PC12 cells.

Two alkaloids isolated from the marine sponge Agelas conifera were tested for interactions with cellular calcium homeostasis. Bromoageliferin and dibromoageliferin reduced voltage-dependent calcium entry in PC12 cells as measured with Fura II as calcium indicator. The half maximal concentration of both alkaloids to reduce voltage-dependent calcium entry was only slightly different: bromoagelife...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:

دوره 15  شماره 

صفحات  -

تاریخ انتشار 2017